$ \sum_{k=0}^{45} \binom{45}{k} {{(-3)}^{2k}} $
$ = \sum_{k=0}^{45} \binom{45}{k} {9}^{k} $
$ = \sum_{k=0}^{45} \binom{45}{k} {9}^{k} {1}^{45-k} $
$= {(1+9)}^{45} $
$= {10}^{45} $