$ = \sum^{20}_{k=0} \binom{20}{k} {(-3x)}^{k} {(5y)}^{20-k} $
$ = \binom{20}{15} {(-3)}^{15} {5}^{5} x^{15} y^5 $
$ = - \binom{20}{15} {(3)}^{15} {5}^{5} x^{15} y^5 $
Thus, the coefficient of $x^{15}y^{5}$ in the expansion of ${(-3x + 5y)}^{20}$ is $ - \binom{20}{15} {(3)}^{15} {5}^{5} $