$=\sum^{25}_{k=0} \binom{25}{k}{(7x)}^k {(21y)}^{25-k}$
$=\binom{25}{16}{(7x)}^{9} {(21y)}^{16}$
$=\binom{25}{16}7^{9} x^{9} {21}^{16} y^{16}$
$=\binom{25}{16}7^{9} x^{9} 3^{16} 7^{16} y^{16}$
$=\binom{25}{16}7^{25} 3^{16} x^{9} y^{16}$
Thus, the coefficient is $\binom{25}{16}7^{25} 3^{16}$