$=\sum^{88}_{k=0} \binom{88}{k}{(3x)}^k {(-17y)}^{88-k}$
$=\binom{88}{7}{(3x)}^{81} {(-17y)}^{7}$
$=\binom{88}{7}3^{81} x^{81} {(-17)}^{7} y^{7}$
$=\binom{88}{7}3^{81} x^{81} {(-17)}^{7} y^{7}$
$=\binom{88}{7}3^{81} {(-17)}^{7} x^{81} y^{7}$
Multiplying a negative number by an odd number of negative numbers results in a negative number.
$=-\binom{88}{7}3^{81} {(17)}^{7} x^{81} y^{7}$